antibody discovery d - sd.

• Build and lead a team for antibody discovery, formatting, developability evaluation, bioconjugation and characterization. • Work with CMC group to establish SOP to scale up antibody production, bioconjugation and downstream processing.

• Optimize infrastructure for the development of antibody-oligonucleotide conjugates.

• Work with internal cross functional team and external partners, identify or build appropriate assays to support development of antibody-oligo nucleotide conjugates.

• Design and execute in vitro and in vivo studies to assess feasibility and timely resolve key issues.

• Mechanistic investigation into the delivery mechanisms and continue to iterate and improve.

• Stay current with the state-of -the-art of targeted oligonucleotide delivery technologies and drive scientific innovation in the field.

skills and experience required.
• PhD in Biology, Bioengineering, or a related field with minimal 10 years of relevant experience in biotech or pharmaceutical industry, with demonstrated track record in basic research and significant contributions to drug discovery. • Prior experience leading antibody-based drug discovery programs into clinical development is a must.

• Prior experience in leading development of antibody oligonucleotide conjugates is highly preferable.

• Must be proficient in antibody discovery, formatting, developability assessments.

• Experienced in downstream processing of antibody and antibody conjugates and scale up.